| Shatnav Ltd | Extraterritorial | 2025 |
| Shaun Clancy's Engineering Limited | Administrative & support | 2015 |
| Shaw Street Fraser Homes Limited | Construction | 2022 |
| Shaw's Property Lettings and Investments Ltd | Real estate | 2017 |
| Shayan Limited | Real estate | 2022 |
| Shaz Kitchen Taste Ltd | Wholesale & retail | 2020 |
| Shazmedical Limited | Health & social care | 2021 |
| Shear Brook Wood Community Interest Company | Health & social care | 2024 |
| Sheevasoftware Ltd | Information & communication | 2022 |
| Sheldon Finch Properties Ltd | Real estate | 2026 |
| Shella Umansky Ltd | Health & social care | 2024 |
| Shepherd Welding Services Limited | Professional & scientific | 2006 |
| Sheppards Group Limited | Financial services | 2024 |
| Sheppards Ltd | Professional & scientific | 2005 |
| Sherborne Sensors Limited | Manufacturing | 2002 |
| Sheriffs Investments Limited | Real estate | 2017 |
| Sherwood Software Consulting Limited | Administrative & support | 2016 |
| Shevin Properties Ltd | Real estate | 2024 |
| Shevlin Properties Limited | Real estate | 2026 |
| SHG Consulting Services Limited | Professional & scientific | 2025 |
| Shieldpay Ltd | Information & communication | 2016 |
| Shieldpay Operations Ltd | Information & communication | 2022 |
| Shieldpay Technologies Limited | Financial services | 2018 |
| Shieldpay Trustee Services Limited | Financial services | 2021 |
| Shiftx BCO Network Ltd | Other services | 2025 |
| Shine Acquisition Co Limited | Financial services | 2017 |
| Shine Dental Limited | Health & social care | 2022 |
| Shine Holdco (UK) Limited | Financial services | 2017 |
| Shine Holdco I Limited | Financial services | 2017 |
| Shine Holdco II Limited | Financial services | 2017 |
| Shine Holdco III Limited | Financial services | 2017 |
| Shine Nominee Limited | Financial services | 2017 |
| Shine Stone Ltd | Real estate | 2026 |
| Shinnock Engineering Limited | Professional & scientific | 2024 |
| Shirley Denyer LLP | | 2012 |
| Shirran Engineering Limited | Professional & scientific | 1990 |
| SHJ Solutions Limited | Administrative & support | 2016 |
| Shlurp Limited | Hospitality | 2002 |
| SHM Properties Ltd | Real estate | 2020 |
| Shoe Express Ltd | Wholesale & retail | 2017 |
| Shoppertainment Group Finance Limited | Financial services | 2024 |
| Shoppertainment Group Holdings Limited | Financial services | 2024 |
| Shoreline Bytes Limited | Information & communication | 2026 |
| Shoshin Consulting Limited | Professional & scientific | 2026 |
| Shot Tower Chester Freehold Limited | Real estate | 2024 |
| Shot Tower Chester Ltd | Construction | 2015 |
| Shotfield Development Business Partnership Limited | Real estate | 2009 |
| Shout! Promotions Limited | Arts & recreation | 1999 |
| Showbase Ltd | Hospitality | 2024 |
| Showlake Limited | Households | 1983 |
| Showroom 77 Ltd | Wholesale & retail | 2024 |
| Showspace UK Ltd | Information & communication | 2026 |
| Shoy's Hire Assistance Limited | Administrative & support | 2008 |
| Shoy's Store Ltd | Wholesale & retail | 2020 |
| Shraina Limited | Professional & scientific | 2024 |
| Shree Hari Halai Consultancy Limited | Professional & scientific | 2022 |
| Shreehari Properties Ltd | Real estate | 2025 |
| Shrish Associates Ltd. | Health & social care | 2015 |
| Sibelitza Ltd | Information & communication | 2014 |
| Sibliance Ltd | Professional & scientific | 2021 |
| Siddhexa Homes Ltd | Real estate | 2023 |
| Siddhexa Private Ltd | Financial services | 2021 |
| Siddiqi Dental Ltd | Health & social care | 2022 |
| Side Street Living Ltd | Construction | 2025 |
| Sidqam Ltd | Information & communication | 2014 |
| Sidwell Consulting Limited | Professional & scientific | 2024 |
| Siem Solutions Limited | Information & communication | 2017 |
| Sienna Rose Ltd | Wholesale & retail | 2023 |
| Sienskin Limited | Professional & scientific | 2024 |
| Sigcontrol Limited | Professional & scientific | 2020 |
| Sigismund Limited | Administrative & support | 2021 |
| Sign Nature Limited | Other services | 1994 |
| SIGN4SPORT Ltd | Administrative & support | 2012 |
| Signal Yellow Limited | Professional & scientific | 2018 |
| Signature Book Representation (UK) Limited | Information & communication | 2009 |
| Sikand and Co PVT Ltd | Health & social care | 2011 |
| Silicon Concepts Limited | Information & communication | 2011 |
| Silkhouse Court Ltd | Construction | 2016 |
| Silkvale Enterprises Limited | Hospitality | 1990 |
| Silobreaker Limited | Information & communication | 2005 |
| Silver Mountain Planning Ltd | Information & communication | 2023 |
| Silver Raven Ltd | Real estate | 2022 |
| Silver Rock Planet Ltd | Wholesale & retail | 2025 |
| Silver Screen Community Films CIC | Information & communication | 2023 |
| Silvercroft Limited | Administrative & support | 2025 |
| Silverdale Investments Ltd | Real estate | 2013 |
| Silverdale Toucan Ltd. | Real estate | 2020 |
| Silverwood Engineering Services Limited | Professional & scientific | 2008 |
| Silvia Benavente Limited | Administrative & support | 2025 |
| SIM Trava (North East) Limited | Hospitality | 2013 |
| SIM Trava (North West) Limited | Hospitality | 2013 |
| SIM Trava Central Services Limited | Administrative & support | 2019 |
| SIM Trava Coffee Limited | Hospitality | 2007 |
| SIM Trava Group Limited | Financial services | 2023 |
| SIM Trava Holdings Limited | Financial services | 2014 |
| SIM Trava Limited | Extraterritorial | 2004 |
| SIM Trava Property Holdings Limited | Financial services | 2023 |
| SIM Trava Property Limited | Real estate | 2019 |
| Simbastyle Limited | Other services | 2017 |
| Simcox Oliver Limited | Information & communication | 2013 |