| Spearfish Racing Ltd | Wholesale & retail | 2014 |
| Spearing & Sons (Booking Solutions) Limited | Administrative & support | 2020 |
| Spearing & Sons (Brentwood) Limited | Other services | 2022 |
| Spearing & Sons (Bury ST Edmunds) Limited | Other services | 2020 |
| Spearing & Sons (Eastbourne) Limited | Other services | 2022 |
| Spearing & Sons (London by Sea) Limited | Other services | 2024 |
| Spearing & Sons (Property) Limited | Real estate | 2025 |
| Spearing & Sons Properties Limited | Other services | 2018 |
| Spearpoint Investments Limited | Real estate | 1963 |
| Specialised Welding Products Limited | Wholesale & retail | 1991 |
| Specialist Wire Rigs Limited | Administrative & support | 2000 |
| Speciality Sourcing and Supply Limited | Wholesale & retail | 2017 |
| Spenser Consulting Services Ltd | Professional & scientific | 2021 |
| Spicer U.K. Limited | Professional & scientific | 1997 |
| Spindle Fuels Ltd | Agriculture & fishing | 2026 |
| Spink Art Ltd | Arts & recreation | 2018 |
| Splash Architecture Ltd | Professional & scientific | 2023 |
| Spring Greening Ltd | Professional & scientific | 2018 |
| Spring Oak Management Ltd | Real estate | 2021 |
| Spring Oak Property Services Ltd | Real estate | 2021 |
| Springvale Avenue Limited | Real estate | 2020 |
| Springwood Upholstery Limited | Manufacturing | 2018 |
| Squires Residential Ltd | Real estate | 2006 |
| SR Biotherapeutics Limited | Professional & scientific | 2026 |
| SSA Property LLP | | 2005 |
| SSL Fund (General Partner) Limited | Real estate | 2006 |
| ST Georges Commercial Management Limited | Real estate | 1989 |
| ST Georges Yard Ltd | Real estate | 2021 |
| ST Helens (T) Hairdressing Limited | Other services | 2004 |
| ST Helens Cadrive Ltd | Administrative & support | 2024 |
| ST Margarets Mews Company Limited | Households | 2011 |
| ST Paul's (T) Hairdressing Limited | Other services | 2001 |
| ST. Katherines (Alton) Limited | Households | 1989 |
| Stagman Limited | Professional & scientific | 2025 |
| Stand 4 Ltd | Construction | 2012 |
| Stand Productions Ltd | Information & communication | 2024 |
| Staplegrove NT LLP | | 2014 |
| Stapleys Welding Inspection & General Limited | Construction | 2009 |
| Star Inn (Bentworth) Limited | Hospitality | 1971 |
| Station Barbers Ltd | Other services | 2016 |
| Station Cafe (2025) Limited | Hospitality | 2025 |
| Step (UK) | Administrative & support | 2007 |
| Stewart Moore Consulting Limited | Information & communication | 2000 |
| Steyne Farm Company Limited | Manufacturing | 2005 |
| Sticker Store Ltd | Professional & scientific | 2023 |
| Sticklands Limited | Professional & scientific | 2009 |
| STO Framing Ltd | Manufacturing | 2023 |
| Stockton Heath (T) Hairdressing Limited | Other services | 2004 |
| Stone Place Developments Limited | Administrative & support | 2007 |
| Stone Place Management Ltd | Real estate | 2004 |
| Stoney Stoke Home Farm Ltd | Agriculture & fishing | 2026 |
| Storm UK Development Ltd | Real estate | 2021 |
| Stormbreaker Consulting Ltd | Professional & scientific | 2021 |
| Stormforce Contractors Ltd | Construction | 2014 |
| Strachan Hall Associates Limited | Professional & scientific | 2004 |
| Stratford House Alton Limited | Households | 2017 |
| Stratford House RTM Company Limited | Households | 2009 |
| Stratford Upon Avon (T) Hairdressing Limited | Other services | 2000 |
| Strathie Film Limited | Information & communication | 2016 |
| Strathmore 11 Limited(The) | Households | 1983 |
| Stratus Estate Limited | Real estate | 2018 |
| Streetcar Productions Limited | Arts & recreation | 2017 |
| Strictly Showtime Ltd | Education | 2022 |
| STS (Ashford) Limited | Wholesale & retail | 2011 |
| Stuart Sharpe Personal Training Limited | Professional & scientific | 2010 |
| Stubbys Stove Installations Limited | Construction | 2023 |
| Studio 252 Ltd | Professional & scientific | 2025 |
| Studio 3 Interiors & Workroom Ltd | Other services | 2022 |
| Studio and Studio Limited | Manufacturing | 2013 |
| Studio Production SPV Limited | Information & communication | 2023 |
| Studio Stone Interiors Limited | Administrative & support | 2025 |
| Studio Stone Ltd | Manufacturing | 2012 |
| STUDIO3 Dental Laboratory Limited | Health & social care | 2016 |
| Style Group Limited | Other services | 1996 |
| Styles & Associates Limited | Professional & scientific | 2013 |
| Styling Management Limited | Administrative & support | 2010 |
| Suade Productions Ltd | Information & communication | 2013 |
| Sudbury (T) Hairdressing Limited | Other services | 2010 |
| SUE Jelley Associates Limited | Real estate | 2006 |
| Suffolk & Watt Solutions Limited | Information & communication | 2001 |
| Suitable Kitchens Ltd | Wholesale & retail | 2016 |
| Summer House Sounds Limited | Wholesale & retail | 2017 |
| Summit Chalets Ltd | Administrative & support | 1998 |
| SUMMIT2BUILD Limited | Manufacturing | 2024 |
| Sumyaan Ltd | Health & social care | 2015 |
| Sunchyme Ltd | Professional & scientific | 2025 |
| Sunken Dreams Limited | Administrative & support | 2006 |
| Sunkyung Shipping Ltd | Transport & logistics | 2011 |
| Sunnyfields Management Limited | Households | 2011 |
| Supreme Clean & Maintenance Limited | Construction | 2017 |
| Surrey & Hampshire Sash Windows Limited | Manufacturing | 2025 |
| Surrey Karate Ltd | Arts & recreation | 2017 |
| Surrey Sash Window Services Ltd | Extraterritorial | 2022 |
| Survaigo Ltd | Information & communication | 2025 |
| Surveyor NOW Ltd | Professional & scientific | 2023 |
| Sustainable Strategies Consulting Ltd | Professional & scientific | 2023 |
| Sustainable Technology Ltd | Construction | 2004 |
| Sutton Coldfield (T) Hairdressing Limited | Other services | 2013 |
| Sutton Coldfield Cadrive Ltd | Administrative & support | 2024 |
| SVP Hampshire Ltd | Administrative & support | 2017 |