| Rossair Limited | Construction | 1973 |
| Rossair Partners LLP | | 2020 |
| Rotargen Limited | Professional & scientific | 2022 |
| Rotherfield Farms LLP | | 2015 |
| Rotrip Ltd | Manufacturing | 2017 |
| Roundhay Pictures Ltd | Information & communication | 2026 |
| Rowand Estates Limited | Real estate | 1935 |
| Royton Steelstock Limited | Wholesale & retail | 1983 |
| RSB Propco (Holdings) Limited | Professional & scientific | 2026 |
| RSB Propco Limited | Real estate | 2026 |
| RTR Care Ltd | Health & social care | 2024 |
| Rural Brewing Company Limited | Wholesale & retail | 2020 |
| Rural Chefs Ltd | Other services | 2024 |
| Rustang Ltd | Administrative & support | 2026 |
| Rwint Digital Limited | Information & communication | 2026 |
| Ryan Ashton Associates Ltd | Professional & scientific | 2014 |
| Ryancris International Limited | Administrative & support | 2025 |
| Rydo Engineering Limited | Manufacturing | 2002 |
| Rynstone Holdings Ltd | Other services | 2016 |
| RZ Circular Ltd | Professional & scientific | 2025 |
| S & H Investments Limited | Real estate | 1961 |
| S & J Residential Renovations and Rental Limited | Real estate | 2018 |
| S & T Property Lettings Limited | Real estate | 2012 |
| S E L Wright Consulting Limited | Health & social care | 2022 |
| S G Heating Limited | Real estate | 2017 |
| S&L Homes and Beyond Ltd | Real estate | 2022 |
| S&S Robinson Holdings Limited | Real estate | 2019 |
| S.G.P Brickwork Ltd | Construction | 2015 |
| S.G.P Investments Ltd | Real estate | 2021 |
| S.K.Y Kebabs Ltd | Hospitality | 2022 |
| S.O.N.O.S. Investments Limited | Other services | 2020 |
| S.O.N.S. Consultancy Limited | Arts & recreation | 2012 |
| S1 Land LLP | | 2026 |
| S2 Land LLP | | 2026 |
| S2PD Fund (General Partner) Limited | Real estate | 2008 |
| S4P Limited | Information & communication | 2013 |
| S5 Land LLP | | 2026 |
| S5PD Fund (General Partner) Limited | Professional & scientific | 2010 |
| SA O'Connell Limited | Financial services | 2025 |
| Saasyn Limited | Wholesale & retail | 2025 |
| Saband Corporation Ltd | Construction | 2020 |
| Sadmin Ltd | Information & communication | 2024 |
| Saes Electrical Ltd | Construction | 2022 |
| Saferoute Solutions Ltd | Professional & scientific | 2024 |
| Safety Welding and Power Tools Ltd | Wholesale & retail | 2015 |
| Saffron Weaver Limited | Professional & scientific | 2014 |
| Saint Media Limited | Information & communication | 2017 |
| Sakura Alton Ltd | Hospitality | 2025 |
| Sale Cadrive Ltd | Administrative & support | 2024 |
| Sales Cipher Ltd | Professional & scientific | 2025 |
| Salford Cadrive Ltd | Administrative & support | 2024 |
| Salland Limited | Administrative & support | 2016 |
| Salnor Roofing Services Limited | Construction | 2002 |
| Salt Pond Management Limited | Administrative & support | 2015 |
| SAM Beech Consulting Ltd | Professional & scientific | 2023 |
| SAM Squared Limited | Manufacturing | 2010 |
| SAM7 Limited | Information & communication | 2001 |
| Sampl Limited | Wholesale & retail | 2017 |
| Sandhurst Interiors Limited | Construction | 2010 |
| Sangam Business Services (UK) Private Limited | Administrative & support | 2024 |
| Sanger Agencies Limited | Construction | 2011 |
| Santina Embroidery London Ltd | Wholesale & retail | 2022 |
| Sapling Arboriculture Limited | Agriculture & fishing | 2005 |
| Sapphire Lapwing Limited | Financial services | 2023 |
| Sapphire Productions Ltd | Information & communication | 2015 |
| Sarah Nightingale Limited | Arts & recreation | 2002 |
| SARN1E Ltd | Professional & scientific | 2014 |
| Sayrosa Holdings Limited | Financial services | 2026 |
| Sazna Limited | Hospitality | 2013 |
| SB Engineering Solutions Limited | Public administration | 2013 |
| SBM Management Services Limited | Financial services | 2016 |
| Scan & WIN Services Ltd | Information & communication | 2020 |
| Scanner Hub Ltd | Information & communication | 2025 |
| Scansation Holdings Ltd | Financial services | 2024 |
| Scansation Ltd | Information & communication | 2005 |
| Scarlet Brambling Limited | Financial services | 2022 |
| Scott 2 Go Limited | Transport & logistics | 2007 |
| Scott Aquaculture Risk Management Limited | Professional & scientific | 2014 |
| Scova Ltd | Administrative & support | 2023 |
| Scribbleit Limited | Wholesale & retail | 2003 |
| Scribeland Limited | Agriculture & fishing | 1981 |
| Sdrplay Limited | Manufacturing | 2014 |
| SDS Matting Limited | Administrative & support | 2009 |
| Sealfix Limited | Wholesale & retail | 1997 |
| Secured by Design Limited | Information & communication | 2023 |
| Securibet Limited | Information & communication | 2003 |
| Security Matterz Ltd | Information & communication | 2012 |
| SEE Change NOW Limited | Manufacturing | 2019 |
| Seed Projects & Management Ltd | Construction | 2014 |
| Seedler Limited | Professional & scientific | 2024 |
| Seerch Technology Limited | Information & communication | 2026 |
| Selborne Biological Services Limited | Manufacturing | 1978 |
| Selborne Guitars Limited | Manufacturing | 2023 |
| Select Funerals Limited | Other services | 2010 |
| Selected Refurbishments Limited | Construction | 2022 |
| Semrah Landscape Management Ltd | Administrative & support | 2010 |
| Sensoli Limited | Manufacturing | 1999 |
| Sentily Ltd | Information & communication | 2023 |
| Sentinel Respiratory Ltd | Wholesale & retail | 2024 |
| Serve I.C.E. Ltd | Manufacturing | 2006 |