| Shanti Pharmaceutical Limited | Administrative & support | 2021 |
| Sherborne Gibbs Limited | Information & communication | 2000 |
| Sherlock Solutioning Limited | Information & communication | 2016 |
| Sherwood Projects Ltd. | Professional & scientific | 2020 |
| Shift Power Ltd | Manufacturing | 2018 |
| Shilpalm Properties Limited | Construction | 1977 |
| Shireoak Homes Limited | Construction | 2016 |
| Shokbox Ltd | Wholesale & retail | 2014 |
| Shokbox Sport Ltd | Manufacturing | 2025 |
| SHOP4ALLSORTS Ltd | Wholesale & retail | 2012 |
| Shucknall Hill Ltd | Transport & logistics | 2022 |
| SI Hall Ltd | Transport & logistics | 2022 |
| Silecroft Ltd | Transport & logistics | 2022 |
| Silvia and Associates Ltd | Health & social care | 2023 |
| Simase Ltd | Real estate | 2022 |
| Simons AGA Services Ltd | Manufacturing | 2025 |
| Simplify IT Solutions Ltd | Information & communication | 2012 |
| Simplify Technology Group Limited | Financial services | 2022 |
| SJ Sports Therapy Limited | Health & social care | 2014 |
| Skelding WM Limited | Professional & scientific | 2020 |
| Skybooks Software Limited | Professional & scientific | 2023 |
| Skydent Denture Clinic Ltd | Health & social care | 2025 |
| SL Transportation Ltd | Manufacturing | 2012 |
| Slant Riggs Limited | Manufacturing | 2005 |
| Slatlater Ltd | Construction | 2019 |
| Slioch Engineering Services Limited | Professional & scientific | 2019 |
| Sliver Years Limited | Real estate | 2025 |
| Small Craft Services Ltd | Professional & scientific | 2011 |
| Smart Circuit Solutions Ltd | Professional & scientific | 2020 |
| Smith Bros. & Webb Limited | Manufacturing | 1936 |
| Snape Plant Limited | Administrative & support | 2022 |
| Sneakypeeks Ltd | Administrative & support | 2012 |
| Software Systems Europe Limited | Information & communication | 1996 |
| Solonova Limited | Professional & scientific | 2020 |
| Soltork Products Limited | Manufacturing | 1997 |
| Songjudges Ltd | Administrative & support | 2019 |
| Sound Choice Vending Ltd | Hospitality | 2025 |
| South Court (Alcester) Management Company Limited | Households | 2023 |
| SP Translations Limited | Professional & scientific | 2015 |
| Space Flea Ltd | Transport & logistics | 2023 |
| Specter Labs Ltd | Information & communication | 2025 |
| Spencer Evans Construction Limited | Construction | 2022 |
| Spice Room Alcester Ltd | Hospitality | 2010 |
| Spicebringer Ltd | Transport & logistics | 2019 |
| Spin Projects Limited | Real estate | 2023 |
| Spirit of Life Coaching Limited | Professional & scientific | 2019 |
| Sports Development Program Ltd | Arts & recreation | 2024 |
| Sports Unit Ltd | Arts & recreation | 2025 |
| Springfield Business Park Management Company Limited | Real estate | 2000 |
| Springlegs Ltd | Construction | 2019 |
| Sprint Valley Limited | Administrative & support | 2017 |
| Sprout and Nurture Limited | Manufacturing | 2025 |
| Square Roost Limited | Real estate | 2019 |
| Squirel Ltd | Professional & scientific | 2025 |
| SSB Property Services Ltd | Construction | 2023 |
| ST. Swift Consulting Limited | Administrative & support | 2011 |
| Stanways Limited | Construction | 1993 |
| Statutory Compliance UK Ltd | Professional & scientific | 2025 |
| Staystrong Ltd | Health & social care | 2025 |
| Steadfast Engineering Company Limited | Manufacturing | 1979 |
| Stellar Consultancy and Training Limited | Professional & scientific | 2020 |
| Steve Jobs PM Limited | Professional & scientific | 2019 |
| Steven Meddoms Ltd | Extraterritorial | 2019 |
| Stiley Holdings Limited | Financial services | 2023 |
| Storpedo Ltd | Transport & logistics | 2019 |
| Stratworth Advisory Ltd | Professional & scientific | 2024 |
| Straubury Creative Concepts Limited | Information & communication | 2018 |
| Strobilus Limited | Professional & scientific | 2021 |
| Strong Feet Ltd | Arts & recreation | 2019 |
| Strong Voices MT Academy LLP | | 2025 |
| Stuart Beare Associates Limited | Extraterritorial | 1977 |
| Stuart Mccabe and Daughter Property Services Limited | Construction | 2008 |
| Studio 111 Clinical Services Limited | Education | 2000 |
| Studio 111 Innovations Limited | Education | 2000 |
| Studio III Training Systems Limited | Education | 1993 |
| Style Installations Graphics Limited | Other services | 2015 |
| Style Swoop Limited | Wholesale & retail | 2024 |
| Stysec Ltd | Manufacturing | 2025 |
| Subside Bar Limited | Hospitality | 2007 |
| Succubusted Ltd | Wholesale & retail | 2019 |
| Sun and Moon Training Limited | Administrative & support | 2006 |
| Sunlover Ltd | Wholesale & retail | 1999 |
| Sunshine Houses Limited | Real estate | 1955 |
| Supa-C Solutions Ltd | Professional & scientific | 2024 |
| Superadditivity Limited | Professional & scientific | 2025 |
| Supreme Customs Ltd | Manufacturing | 2021 |
| Supreme Scissors Barber Shop Ltd | Other services | 2025 |
| Suprpwr Consulting Limited | Professional & scientific | 2025 |
| Sustainable Product Designs Limited | Professional & scientific | 2022 |
| Sutton Road Tax Services Limited | Professional & scientific | 2002 |
| SVS Lettings Ltd | Real estate | 2020 |
| SW Creations Ltd | Professional & scientific | 2026 |
| SW Scaffolding Services Ltd | Construction | 2023 |
| Swain ENG Ltd | Professional & scientific | 2017 |
| Swan Street Services Limited | Administrative & support | 2021 |
| Swinsper Contract Services Limited | Construction | 2002 |
| Sxpress Ltd | Wholesale & retail | 2022 |
| Synergica UK Ltd | Information & communication | 2024 |
| Syspro Consulting Limited | Professional & scientific | 2001 |
| T.P.E. Transportation Ltd | Transport & logistics | 2020 |