| Safest Electrical Limited | Construction | 2018 |
| Safestream Engineering Ltd | Professional & scientific | 2020 |
| Safetec UK Limited | Mining & quarrying | 2003 |
| Safetest Compliance Services Ltd | Construction | 2012 |
| Safety & Technical Hydraulics Limited | Manufacturing | 2005 |
| Safety Collaborations Limited | Professional & scientific | 2020 |
| Safety Compliance and Training Consultancy Ltd | Professional & scientific | 2026 |
| Safety Guardian UK Limited | Information & communication | 2026 |
| Safety Scotland Limited | Administrative & support | 2004 |
| Safetygrip Solutions Ltd | Manufacturing | 2011 |
| Safetynet Scotland Limited | Other services | 2006 |
| Safeworks (Scotland) Limited | Professional & scientific | 2015 |
| Saffron & Clay Ltd | Hospitality | 2026 |
| Sagars Accountants Ltd | Professional & scientific | 2023 |
| Sage & Rose Atelier Ltd | Hospitality | 2023 |
| Sage Legal Limited | Professional & scientific | 2021 |
| Sagehub Ltd | Information & communication | 2025 |
| Sagittarii Ltd | Professional & scientific | 2017 |
| SAH Communications Limited | Professional & scientific | 2026 |
| SAH Process Consultants Ltd | Administrative & support | 2011 |
| Sahar Motors Limited | Wholesale & retail | 2024 |
| Sahara UK Foods Ltd | Wholesale & retail | 2017 |
| SAI Dheer Realty Ltd | Real estate | 2026 |
| SAI Sithara Ltd | Information & communication | 2022 |
| Saigon Property Limited | Hospitality | 2025 |
| Saima Food Ltd | Hospitality | 2024 |
| Saipri Limited | Health & social care | 2011 |
| Sajjdeen Ltd | Wholesale & retail | 2022 |
| Sajjdeenproperty Limited | Real estate | 2023 |
| Saker Consultancy Group Ltd | Professional & scientific | 2021 |
| Sakkara Inter LP | | 2013 |
| Sakr Investment Ltd | Real estate | 2024 |
| Salamander Wind Project Company Ltd | Energy | 2020 |
| Salburn Ltd | Administrative & support | 2025 |
| Saleologa Mill LP | | 2013 |
| Saleout Ltd | Wholesale & retail | 2025 |
| Sales&Setting Ltd | Wholesale & retail | 2025 |
| Salman Catering Limited | Hospitality | 2025 |
| Salmas Staytech Limited | Information & communication | 2025 |
| Salmik Ltd | Wholesale & retail | 2024 |
| Salmon Heating Services Ltd | Construction | 2021 |
| Salom (J S) Limited | Wholesale & retail | 2009 |
| Salon 70 Limited | Other services | 2023 |
| Saltire Competitions Ltd | Arts & recreation | 2025 |
| Saltire Drilling Tools Limited | Mining & quarrying | 2011 |
| Saltire Energy (Norway) Limited | Mining & quarrying | 2012 |
| Saltire Energy Limited | Mining & quarrying | 1996 |
| Saltire Energy Tubular Services Limited | Manufacturing | 2019 |
| Saltire Holdings Limited | Construction | 2020 |
| Saltire Preparation Ltd | Construction | 2021 |
| Saltire Pressure Control Limited | Manufacturing | 1989 |
| Saltsea Limited | Agriculture & fishing | 2004 |
| Salus Technical Limited | Information & communication | 2015 |
| Salvation Ministries (Home of Success) Scotland | Other services | 2021 |
| SAM & Amy’S Nail Salon Ltd | Other services | 2025 |
| SAM and Sholz Limited | Real estate | 2021 |
| SAM Andrew Solutions Ltd | Administrative & support | 2000 |
| SAM Clears Cleaning Services Ltd | Administrative & support | 2025 |
| SAM IT Services (UK) Limited | Information & communication | 2005 |
| Sami Logistics Ltd | Transport & logistics | 2025 |
| Sami Services Ltd | Other services | 2024 |
| Samir's Barber Shop Ltd | Other services | 2024 |
| Samjay Global Ltd | Manufacturing | 2025 |
| Sammtek Ltd | Professional & scientific | 2013 |
| Samphier Consulting Limited | Information & communication | 2025 |
| Samsoyombo Career Pathways Ltd | Administrative & support | 2024 |
| Samuri Conversions Silverstone Circuit Limited | Construction | 2014 |
| Sanaland Ltd | Real estate | 2023 |
| Sanctuary House Hotel Ltd | Hospitality | 2025 |
| Sanctuary House Ltd | Hospitality | 2026 |
| Sand Entertainment Ltd | Hospitality | 2026 |
| Sand Management Services Limited | Professional & scientific | 2009 |
| Sand Monitoring Services (Holdings) Limited | Mining & quarrying | 2008 |
| Sand Monitoring Services Limited | Mining & quarrying | 2004 |
| Sanday Properties Ltd | Construction | 2011 |
| Sandend Capital Partners Limited | Professional & scientific | 2012 |
| Sandend Investments Limited | Real estate | 2009 |
| Sandhu Peri Peri Ltd | Hospitality | 2024 |
| Sandison Kennedy Limited | Professional & scientific | 2018 |
| Sandrachaircovers Limited | Wholesale & retail | 2009 |
| Sandy Martin Design Ltd | Administrative & support | 2017 |
| Sandy's Fish and Chips Limited | Hospitality | 2024 |
| Sangama (Aberdeen) Limited | Real estate | 2023 |
| Sangs Catering Limited | Hospitality | 2024 |
| Sangster & Annand Slaters Ltd. | Construction | 2017 |
| Sangster Drilling Consultants Limited | Other services | 2012 |
| Sangster Investment Property Group Ltd | Real estate | 2024 |
| Sangster Property Management Limited | Real estate | 2020 |
| Sanine Engineering Ltd | Professional & scientific | 2024 |
| Sanjay a Retail Ltd | Wholesale & retail | 2026 |
| Sanmac Supplies Ltd | Wholesale & retail | 1981 |
| Sanmio Limited | Wholesale & retail | 2020 |
| Santana Barber Limited | Other services | 2024 |
| Santi Property Investments Limited | Real estate | 2024 |
| Saothar Limited | Professional & scientific | 2016 |
| Saphire Engineering Services Limited | Professional & scientific | 2019 |
| Sapmap Limited | Wholesale & retail | 2001 |
| Sapphire Orthodontics Limited | Health & social care | 2014 |
| Saprra Properties Ltd | Real estate | 2024 |
| Sarah Forde Ltd | Financial services | 2021 |