| Dollheads Hair & Beauty Limited | Other services | 2016 |
| DR (102) Limited | Hospitality | 2013 |
| DR H V Mclay Clinical Psychology Limited | Health & social care | 2024 |
| Dronear Ltd | Professional & scientific | 2024 |
| Dunholm Estates Ltd. | Real estate | 2021 |
| Dupla Solutions Ltd | Professional & scientific | 2025 |
| Durham Chef Limited | Hospitality | 2023 |
| Durham Scientific Limited | Professional & scientific | 2022 |
| ECS GAS Training North East Ltd | Education | 2016 |
| Eden Grange Fishery Ltd | Agriculture & fishing | 2021 |
| Eden Grange Leisure Limited | Hospitality | 2019 |
| Eden Grange Tepee Wedding Venue Ltd | Hospitality | 2019 |
| EJA Houndgate Townhouse Limited | Hospitality | 2021 |
| Eldon Hall Farm Steadings Limited | Households | 2018 |
| Elite Lettings & Property Management Limited | Real estate | 2019 |
| Elite Lettings Maintenance Limited | Other services | 2022 |
| ELOC8 Ltd | Manufacturing | 2015 |
| ELOC8 Software Solutions Ltd | Information & communication | 2021 |
| EN UBA Ltd | Health & social care | 2026 |
| Engin Yard Beverage Co. Ltd | Other services | 2017 |
| EVA Holdings Ltd | Real estate | 2025 |
| Eztech-Magik Ltd | Professional & scientific | 2024 |
| Ferryhill Roofing Contractors Limited | Construction | 2015 |
| FJ Estates NE Limited | Real estate | 2017 |
| Foodroo Ltd | Hospitality | 2025 |
| Fostering Forensics Ltd | Professional & scientific | 2018 |
| FOX Accounting Services Ltd | Professional & scientific | 2019 |
| FOX Accounting Solutions Ltd | Administrative & support | 2021 |
| Frith Engineering Ltd | Construction | 2024 |
| Frith Properties Ltd | Real estate | 2025 |
| Full Works BBQ and Grill Limited | Hospitality | 2023 |
| G & L Blooms Ltd | Wholesale & retail | 2024 |
| G B Communications Ltd | Manufacturing | 2023 |
| Gentian Counselling and Psychotherapy CIC | Health & social care | 2024 |
| George Samuel Brewery Ltd | Manufacturing | 2020 |
| Glenco Supplies Ltd | Manufacturing | 2025 |
| Gold Leader Games Limited | Information & communication | 2024 |
| Graham Caygill Limited | Construction | 2016 |
| Grass 4 Home Limited | Extraterritorial | 2020 |
| Gretpark Properties Limited | Real estate | 2001 |
| Hackett RAS Limited | Manufacturing | 2013 |
| Hackworth Accounting Limited | Professional & scientific | 2011 |
| Hackworth Homes Limited | Real estate | 2026 |
| Hackworth Park Properties Limited | Professional & scientific | 2013 |
| Happy Barista Coffee Company Limited | Hospitality | 2021 |
| Hayfields Contracting Limited | Administrative & support | 2007 |
| Help First AID Training Limited | Health & social care | 2009 |
| Hilarity Bites Limited | Professional & scientific | 2018 |
| Homing Heroes CIC | Construction | 2025 |
| Hot Plate Catering Services Ltd | Hospitality | 2024 |
| Huckleberry Roofing Ltd | Construction | 2026 |
| Humbles Garage Limited | Wholesale & retail | 2013 |
| Hygge Enterprises Ltd | Manufacturing | 2022 |
| Hygge Franchise Limited | Manufacturing | 2026 |
| I & M Engineering Consultants UK Ltd. | Construction | 2009 |
| I.K. Internationall Ltd. | Wholesale & retail | 2022 |
| IO Data Limited | Information & communication | 2015 |
| J Beal Waste Metal Recycling Limited | Wholesale & retail | 2021 |
| J D & M a Hicks Limited | Administrative & support | 2012 |
| J Denham Metals Ltd | Wholesale & retail | 2009 |
| J Maguire Holdings Limited | Financial services | 2009 |
| J W Mchaul Limited | Transport & logistics | 2019 |
| Jack Coupe & Sons Limited | Construction | 2010 |
| Jaydee Associates Limited | Other services | 2003 |
| JB Arboriculture Ltd | Agriculture & fishing | 2024 |
| JDS Automotive Limited | Wholesale & retail | 2024 |
| JDS Motor Company Ltd | Wholesale & retail | 2022 |
| Jlsv Properties Limited | Real estate | 2023 |
| Jlsv Retail Limited | Wholesale & retail | 2023 |
| JS Home Touch Care Services Limited | Public administration | 2024 |
| Jubilee Fields Community Association | Other services | 2004 |
| JVA Precision Engineering Ltd | Manufacturing | 2002 |
| K & S TM Ltd | Construction | 2023 |
| KC Cladding (NE) Limited | Construction | 2025 |
| KD Cars NE Limited | Administrative & support | 2026 |
| Kellars Limited | Wholesale & retail | 2001 |
| Kivra Enterprise Ltd | Information & communication | 2026 |
| Koliam Limited | Manufacturing | 2015 |
| Korp Holdings Limited | Financial services | 2025 |
| KPD Distribution Ltd | Manufacturing | 2021 |
| KS Medical Solutions Ltd | Health & social care | 2018 |
| L&S Industrial Cladding Ltd | Construction | 2019 |
| Leadbetter Staircases and Joinery Services Limited | Construction | 2022 |
| LEE Harle LEE Ltd | Real estate | 2012 |
| LEE Thompson Cladding Limited | Construction | 2016 |
| Legatum Holdings Ltd | Financial services | 2016 |
| Liam Kavanagh Limited | Construction | 2016 |
| Liberty Drums Limited | Extraterritorial | 2010 |
| Lindens Investments Limited | Real estate | 2015 |
| Ling Group Limited | Administrative & support | 2023 |
| Longs Construction Limited | Construction | 2017 |
| LT Brickworks Ltd | Construction | 2018 |
| Lulu and Blush Ltd | Wholesale & retail | 2021 |
| Lutterington Holdings Limited | Financial services | 2022 |
| M Spence Surfacing Limited | Construction | 2015 |
| M.E.A Solutions (NE) Ltd | Financial services | 2023 |
| Manases Maya Camayo Ltd | Hospitality | 2020 |
| Manhealth CIC | Health & social care | 2015 |
| Marco Building Services Limited | Construction | 2017 |
| Mark Media Ltd | Information & communication | 2024 |